![]() P38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 ![]() HIV-1 gp120 is potentially cytotoxic to human cells through the induction of p53, which may eventually lead to induction of apoptosisĬaspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons HIV-1 Env gp120 treatment activates TP53 (p53) which contributes to the upregulation of the mitochondrial redox enzyme PRODH (POX) HIV-1 Env gp120 induces TP53 (p53) via binding to the CXCR4 co-receptor Latent HIV infection increases TP53 (p53) expression and phosphorylation Expression Ubiquitous expression in spleen (RPKM 13.2), lymph node (RPKM 13.1) and 25 other tissues See more Orthologs mouse all NEW Try the new Gene table Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). ![]() Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Full Name tumor protein p53 provided by HGNC Primary source HGNC:HGNC:11998 See related Ensembl:ENSG00000141510 MIM:191170 AllianceGenome:HGNC:11998 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as P53 BCC7 LFS1 BMFS5 TRP53 Summary This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |